Nicotine Use Tied to Teen Anxiety and Depression Risk
Published July 24, 2026

Adolescents who use nicotine, whether through cigarettes, vapes or nicotine pouches, are more likely to report anxiety, depression, and other mental health symptoms than peers who don’t. New research out of the University of Gothenburg pointed out that girls appear especially vulnerable. One study found that nearly 80% of girls who used nicotine reported anxiety symptoms.
Linking Addictions to Mental Health
The findings come from three related studies examining tobacco use and youth mental health. In one, researchers surveyed almost 3,000 Swedish high school students and found the association between nicotine use and anxiety symptoms held for both traditional tobacco products and tobacco-free nicotine products like pouches and e-cigarettes, suggesting the connection isn’t limited to smoking specifically.
A second, longer-running study followed roughly 1,500 adolescents from lower secondary school through high school. Depressive symptoms and suicidal ideation were more common among teens who took substances, including smoking. Girls who started smoking more and more over time tended to report worsening sleep problems, anxiety, low mood, and difficulty concentrating.
Other studies have also linked smoking cannabis to mental health.
Co-Occurring Disorders Among Young People
When a substance use pattern and a mental health condition show up together, clinicians describe that as co-occurring disorders, sometimes called dual diagnosis. A dependence on nicotine and stronger substances commonly pair with anxiety or depression, and the relationship tends to run in both directions. Nicotine withdrawal can produce anxiety-like symptoms, and people already afflicted with anxiety or low mood may smoke as a coping tool, which can deepen dependence over time without addressing the underlying symptoms.
A related animal study cited alongside this research found that nicotine produced sex- and region-specific changes in a brain area involved in stress and emotional processing. Effects that differed by sex could be partly reversed through motor-skill training. While that work was done in rodents, it adds a possible biological mechanism to the pattern researchers see in teenagers.
Integrated Treatment Matters
Treating nicotine dependence and a mental health condition as two separate, unrelated problems often misses how closely they interact. A treatment plan that only addresses nicotine use, without also screening for and treating anxiety or depression, risks leaving the underlying symptoms that drove nicotine use in the first place unaddressed. The reverse is also true. Inpatient or outpatient mental health treatment that doesn’t account for nicotine dependence may see limited progress if withdrawal symptoms keep resurfacing.
Effective approaches for adolescents facing this combination typically include:
- Cognitive behavioral therapy (CBT) with peer support adapted for co-occurring nicotine dependence and anxiety or depression
- Screening for mental health symptoms as a standard part of any nicotine cessation rehab program for teens, not an afterthought
- Family-inclusive treatment models and interventions, since parents and caregivers often notice mood or behavior changes before a teen discloses nicotine use
- Medication management when appropriate, coordinated between a prescribing clinician and a therapist rather than managed in isolation
Treatment for All Family Members
Parents and caregivers who notice a teen using nicotine products alongside signs of withdrawal from friends, declining grades, or persistent low mood, don’t need to address these as separate problems. A single evaluation can screen for both.
Here’s where we come in. Call 800-908-4823 (Sponsored) to speak with an expert and find local resources to help with smoking and other health conditions. You can also search our directory for facilities and programs anywhere in the country.
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